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This biomarker is also known as:
  • receptor-type tyrosine-protein phosphatase epsilon,
  • PTPE,
  • protein tyrosine phosphatase, receptor type, E,
  • protein tyrosine phosphatase, receptor type, epsilon polypeptide,
  • EC,
  • Protein-tyrosine phosphatase epsilon,
  • R-PTP-epsilon,
  • HPTPE,

View in BioMuta


PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. The PTPRE gene encodes two isoforms, one of which is a receptor-type PTP, and the other which is not a receptor-type PTP. Both isoforms act as negative regulators of FceRI-mediated signal transduction leading to cytokine production and degranulation.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

PTPRE was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.