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PQBP1

Basics

Aliases:
This biomarker is also known as:
  • polyglutamine binding protein 1,
  • polyglutamine-binding protein 1,
  • polyglutamine tract-binding protein 1,
  • Polyglutamine tract-binding protein 1,
  • mental retardation, X-linked 55,
  • RENS1,
  • MRX55,
  • PQBP-1,
  • Npw38,
  • 38 kDa nuclear protein containing a WW domain,
  • MRXS3,
  • nuclear protein containing WW domain 38 kD,
  • NPW38,
  • MRXS8,
  • Sutherland-Haan X-linked mental retardation syndrome,
  • SHS,

View in BioMuta

Description…

From NCBI Gene: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: PQBP1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Curated

Overview

No additional prostate data available.

Performance Comment

Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement