Aliases:This biomarker is also known as:
- Osteoblast-specific factor 2,
- periostin, osteoblast specific factor,
POSTN, a secreted protein, binds to heparin and induces cell attachment and spreading. It may additionally play a role in cell adhesion and in extracellular matrix mineralization. POSTN is widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. It is up-regulated in epithelial ovarian tumors while not expressed in normal ovaries. POSTN is also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. It is overexpressed in breast cancers.
|QA State:||Under Review|
There are no datasets associated with this biomarker.