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POLR2L

Basics

Aliases:
This biomarker is also known as:
  • RPB10 homolog,
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
  • RPB7.6,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • hsRPB10b,
  • RPB10,
  • DNA-directed RNA polymerase III subunit L,
  • RNA polymerase II 7.6 kDa subunit,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • RPABC5,
  • RNA polymerases I, II, and III subunit ABC5,
  • RBP10,
  • RPB10beta,
  • hRPB7.6,

View in BioMuta

Description…

POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: POLR2L

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 12/02/2014

New Round of EDRN FOAs

The RFAs for EDRN have been released:
- Biomarker Developmental Laboratories (U01),
- Clinical Validation Centers (U01),
- Biomarker Reference Laboratories (U24),
- Data Management and Coordinating Center (U24).

EDRN Renewal flyer NOTE-New receipt deadline for applications submitted for all EDRN FOAs is January 20, 2015, by 5:00 PM local time of applicant organization.

There will be a Pre-Application webinar to discuss each of the four individual EDRN FOAs on Tuesday, December 2nd, 2014, from 1pm-5pm (Eastern). Potential applicants interested in participating in the webinar should send a message to Dr. Sharmistha Ghosh (ghoshjanjigias@mail.nih.gov) no later than 5:00 p.m. (EST) November 21, 2014. Please mention the FOA of interest in the subject line.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.