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This biomarker is also known as:
  • RPABC5,
  • RNA polymerase II 7.6 kDa subunit,
  • RNA polymerases I, II, and III subunit ABC5,
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • RPB10,
  • hsRPB10b,
  • RPB10 homolog,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • DNA-directed RNA polymerase III subunit L,
  • hRPB7.6,
  • RPB7.6,
  • RPB10beta,
  • RBP10,

View in BioMuta


POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.