Aliases:This biomarker is also known as:
- RNA polymerases I, II, and III subunit ABC5,
- DNA-directed RNA polymerases I, II, and III subunit RPABC5,
- polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
- DNA-directed RNA polymerase III subunit L,
- RNA polymerase II 7.6 kDa subunit,
- polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
- RPB10 homolog,
POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.