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POLR2L

Basics

Aliases:
This biomarker is also known as:
  • hRPB7.6,
  • RPB10,
  • RPB7.6,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • RPB10 homolog,
  • DNA-directed RNA polymerase III subunit L,
  • RPABC5,
  • RNA polymerase II 7.6 kDa subunit,
  • RPB10beta,
  • RBP10,
  • hsRPB10b,
  • RNA polymerases I, II, and III subunit ABC5,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,

View in BioMuta

Description…

POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: POLR2L

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement