Aliases:This biomarker is also known as:
- Formylglycinamide ribotide amidotransferase,
- FGAM synthase,
- Formylglycinamide ribotide synthetase,
- phosphoribosylformylglycinamidine synthase,
- FGAR amidotransferase,
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The PFAS enzyme catalyzes the fourth step of IMP biosynthesis. This step is: ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
|QA State:||Under Review|
There are no datasets associated with this biomarker.