Aliases:This biomarker is also known as:
- procollagen C-proteinase enhancer 1,
- procollagen C-endopeptidase enhancer,
- procollagen, type 1, COOH-terminal proteinase enhancer,
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. PCOLCE is a secreted glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.
|QA State:||Under Review|
There are no datasets associated with this biomarker.