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MYC

Basics

Aliases:
This biomarker is also known as:
  • v-myc avian myelocytomatosis viral oncogene homolog,
  • myc-related translation/localization regulatory factor,
  • Transcription factor p64,
  • Myc proto-oncogene protein,
  • v-myc myelocytomatosis viral oncogene homolog (avian),
  • avian myelocytomatosis viral oncogene homolog,
  • myc proto-oncogene protein,
  • c-Myc,
  • bHLHe39,
  • Class E basic helix-loop-helix protein 39,
  • cmyc,
  • BHLHE39,
  • Proto-oncogene c-Myc,
  • MRTL,

View in BioMuta

Description…

The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It participates in the regulation of gene transcription of specific target genes. MYC binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of the MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Evidence shows that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini.

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: MYC

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

MYC, or c-MYC, amplification has been implicated in primary breast cancer through multiple studies over the years. The MYC amplification correlates with disease progression and recurrence.

Performance Comment

MYC was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

MYC is an important oncogene in lung cancer. It is expressed in a large number of non-small cell lung cancers (NSCLCs). Gene amplification at 8q24 and resultant increased expression of MYC is a common occurrence in carcinomas. It leads to increased formation of the MYC:Max heterodimer transcription factors that alter gene expression in large part by recruiting histone-modifying enzymes.

Performance Comment

When assessed as a candidate biomarker signature predictive of lung cancer, the sensitivity of presence of abnormality in TP63, MYC, CEP3, and CEP6 was 82% and specificity was 58%. The receiver operating characteristic (ROC) curves show the added value of histology and epidemiological information, ultimately achieving an area under the curve of 92.6%. The demographic information represents gender, age, pack years of smoking history, and smoking status. The differences between the curves were significant between demographics vs. demographics and cytology (p = 0.02) or vs. demographics, cytology and 4 FISH biomarkers (TP63, MYC, CEP3, CEP6) (p = 0.002). Although showing a trend, the difference was not significant between demographics and cytology vs. demographics, histology and 4 FISH biomarkers (p = 0.11).

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 11/20/2014

New Round of EDRN FOAs

The RFAs for EDRN have been released:
- Biomarker Developmental Laboratories (U01),
- Clinical Validation Centers (U01),
- Biomarker Reference Laboratories (U24),
- Data Management and Coordinating Center (U24).

EDRN Renewal flyer NOTE-New receipt deadline for applications submitted for all EDRN FOAs is January 20, 2015, by 5:00 PM local time of applicant organization.

There will be a Pre-Application webinar to discuss each of the four individual EDRN FOAs on Tuesday, December 2nd, 2014, from 1pm-5pm (Eastern). Potential applicants interested in participating in the webinar should send a message to Dr. Sharmistha Ghosh (ghoshjanjigias@mail.nih.gov) no later than 5:00 p.m. (EST) November 21, 2014. Please mention the FOA of interest in the subject line.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.