This biomarker is also known as:
- metallophosphoesterase domain containing 2,
- Fetal brain protein 239,
- Metallophosphoesterase domain-containing protein 2,
- metallophosphoesterase domain-containing protein 2,
- fetal brain protein 239,
- chromosome 11 open reading frame 8,
- EC 3.1.-.-,
- metallophosphoesterase MPPED2,
View in BioMuta
MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). Alternatively spliced transcript variants have been described.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Mpped2 expression has been shown to impair neuroblastoma tumorigenesis in mice.
MPPED2 (C11ORF8) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. MPPED2 (C11ORF8) was not in the group of 13 selected for further validation.
This biomarker is currently being annotated or is under review.
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Update: Pre-application webinar information now available.
The National Cancer Institute's Division of Cancer Prevention has released a new funding opportunity to solicit organ-specific applications for Biomarker Developmental Laboratories (BDLs), one of the four scientific units of the recently funded Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. BDLs are responsible for the discovery, development, characterization, and testing of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of cancers.
The existing BDLs are primarily focused on ovary and gastrointestinal cancers. The proposed BDLs (to be supported under this funding opportunity) should be focused on one or more of the following cancers: breast, prostate and other genitourinary organs, or lung. In addition, cancers with rapidly rising incidence rates, e.g., endometrial, hepatocellular, kidney, thyroid, oropharyngeal cancers, and/or cancers with unique etiology, e.g., mesothelioma, will be considered.
The newly funded units of the Early Detection Research Network will be announced later in April. Successful applicants have already been notified. Those researchers who were not successful during the last round of applications are encouraged to apply to this opportunity.