Aliases:This biomarker is also known as:
- Melanoma cell adhesion molecule,
- S-endo 1 endothelial-associated antigen,
- Melanoma-associated antigen A32,
- CD146 antigen,
- Melanoma-associated antigen MUC18,
- cell surface glycoprotein MUC18,
- cell surface glycoprotein P1H12,
- melanoma adhesion molecule,
- melanoma cell adhesion molecule,
- melanoma-associated antigen A32,
- Cell surface glycoprotein P1H12,
- melanoma-associated antigen MUC18,
From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Head & neck, NOS
No additional data available.
MCAM is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.
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