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MCAM

Basics

Aliases:
This biomarker is also known as:
  • CD146 antigen,
  • CD146,
  • Cell surface glycoprotein P1H12,
  • S-endo 1 endothelial-associated antigen,
  • MUC18,
  • melanoma-associated antigen MUC18,
  • cell surface glycoprotein MUC18,
  • Melanoma-associated antigen A32,
  • melanoma-associated antigen A32,
  • Gicerin,
  • melanoma adhesion molecule,
  • cell surface glycoprotein P1H12,
  • Melanoma cell adhesion molecule,
  • melanoma cell adhesion molecule,
  • Melanoma-associated antigen MUC18,

View in BioMuta

Description…

From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: MCAM

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Head & neck, NOS

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

MCAM is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement