Aliases:This biomarker is also known as:
- c-Kirsten-ras protein,
- PR310 c-K-ras oncogene,
- cellular c-Ki-ras2 proto-oncogene,
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog,
- K-ras p21 protein,
- Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog,
- c-K-ras2 protein,
- transforming protein p21,
- oncogene KRAS2,
The KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
|QA State:||Under Review|
There are no datasets associated with this biomarker.