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KLK6

Basics

Aliases:
This biomarker is also known as:
  • kallikrein-related peptidase 6,
  • PRSS9,
  • SP59,
  • KLK-6,
  • Neurosin,
  • PRSS18,
  • Klk7,
  • Serine protease 18,
  • Kallikrein-6,
  • Zyme,
  • Serine protease 9,
  • Protease M,
  • Bssp,
  • HK-6,

View in BioMuta

Description…

Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Overexpressed in primary breast tumors but not expressed in metastatic tumors.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: KLK6

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Three
QA State: Accepted

Overview

Amplification of a chromosome 19q region with the entire kallikrein family associated with ovarian cancer.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. KLK6 alone was not a strong predictor.

Supporting Study Data

The following studies/protocols provide evidence supporting KLK6 indications for the Ovary…

PLCO Ovarian Phase III Validation Study

Our preliminary data indicate that the performance of CA 125 as a screening test for ovarian cancer can be improved upon by additional biomarkers. With completion of one additional validation step, we will be ready to test the performance of a consensus marker panel in a phase III validation study. Given the original aims of the PLCO trial, we believe that the PLCO represents an ideal longitudinal cohort offering specimens for phase III validation of ovarian cancer biomarkers.

View more about this study
Biomarker Characteristics Summary
Notes Sensitivity Specificity Prevalence NPV PPV Specific Assay Type
For all cases, using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 22.0 95.0 N/A N/A N/A
For early stage (more than 12 months prior to diagnosis), using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 28.0 95.0 N/A N/A N/A
For late stage (within 12 months of diagnosis), using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 14.0 95.0 N/A N/A N/A
Decision Rule

PMID:21372037

Additional Study-Specific Protocols
Study-Specific Publications

No study-specific publications defined.

Study-Specific Resources

No study-specific resources defined.

SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 late-staged cases, 160 controls with benign disease, 480 general population controls, and a small set of serial Samples collected either at least 3 months apart, but not more than 6 months apart OR between 10 months apart and no more than 14 months apart in 40 healthy controls) will be used to evaluate markers identified in preliminary work. The top 5-10 markers, plus an expanded panel of Luminex markers, will comprise a “working consensus panel” for subsequent analysis in PLCO specimens.

View more about this study
Biomarker Characteristics Summary
Notes Sensitivity Specificity Prevalence NPV PPV Specific Assay Type
For all cases, using all controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 24.0 95.0 N/A N/A N/A
For early stage (more than 12 months prior to diagnosis), using all controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 28.0 95.0 N/A N/A N/A
For late stage (within 12 months of diagnosis), using all controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 18.0 95.0 N/A N/A N/A
For all cases, using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 22.0 95.0 N/A N/A N/A
For early stage (more than 12 months prior to diagnosis), using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 28.0 95.0 N/A N/A N/A
For late stage (within 12 months of diagnosis), using general population controls. Results from preliminary analysis, 50% of 114 sample set. Daniel Cramer laboratory. 14.0 95.0 N/A N/A N/A
Decision Rule

PMID:21372037

Additional Study-Specific Protocols
Study-Specific Publications

No study-specific publications defined.

Study-Specific Resources

No study-specific resources defined.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Publications

No associated publications found.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement