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This biomarker is also known as:
  • NAF,
  • MONAP,
  • neutrophil-activating peptide 1,
  • Monocyte-derived neutrophil-activating peptide,
  • T-cell chemotactic factor,
  • Protein 3-10C,
  • MDNCF,
  • interleukin-8,
  • LYNAP,
  • 3-10C,
  • GCP1,
  • small inducible cytokine subfamily B, member 8,
  • LECT,
  • chemokine (C-X-C motif) ligand 8,
  • emoctakin,
  • T cell chemotactic factor,
  • AMCF-I,
  • LUCT,
  • beta-thromboglobulin-like protein,
  • Granulocyte chemotactic protein,
  • lymphocyte-derived neutrophil-activating factor,
  • OTTHUMP00000199825,
  • NAP1,
  • Neutrophil-activating protein 1,
  • IL-8,
  • GCP-1,
  • interleukin 8,
  • CXCL8,
  • C-X-C motif chemokine 8,
  • Emoctakin,
  • NAP-1,

View in BioMuta


Interleukin 8 (IL8) is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts neutrophils, basophils, and T-cells, but not monocytes. IL8 is one of the major mediators of the inflammatory response, and is involved in neutrophil activation. It is released from several types of cells in response to an inflammatory stimulus. IL8 also functions as an angiogenic factor. The IL8 gene maps to chromosome 4q, and is found in a chemokine gene cluster along with ten other members of the CXC chemokine gene family. There are several N-terminal processed forms that are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. Among the forms are: IL-8(1-77), IL-8(5-77), IL-8(6-77), IL-8(7-77), IL-8(8-77), IL-8(9-77). IL-8(1-77) is generally referred to as interleukin 8. IL-8(6-77) is the most promiment form.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: IL8


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


Performance Comment

Levels of IL8 in exhaled breath condensate indicated acute inflammation but were not indicative of lung cancer.



Phase: Two
QA State: Under Review


IL8 alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.



Phase: One
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.