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This biomarker is also known as:
  • 17b-HSD10,
  • short chain L-3-hydroxyacyl-CoA dehydrogenase type 2,
  • Mitochondrial ribonuclease P protein 2,
  • 17-beta-hydroxysteroid dehydrogenase 10,
  • mental retardation, X-linked, syndromic 10,
  • 17-beta-HSD 10,
  • hydroxysteroid (17-beta) dehydrogenase 10,
  • DUPXp11.22,
  • short chain dehydrogenase/reductase family 5C, member 1,
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase,
  • MRX17,
  • ERAB,
  • MRXS10,
  • SDR5C1,
  • amyloid-beta peptide binding alcohol dehydrogenase,
  • MRX31,
  • EC,EC,
  • MRPP2,
  • HADH2,
  • 3-hydroxyacyl-CoA dehydrogenase type-2,
  • hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme A dehydrogenase, type II,
  • SCHAD,
  • short chain type dehydrogenase/reductase XH98G2,
  • endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • AB-binding alcohol dehydrogenase,
  • Type II HADH,
  • ABAD,
  • XH98G2,
  • CAMR,
  • Mitochondrial RNase P protein 2,
  • HCD2,
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • MHBD,
  • 3-hydroxyacyl-CoA dehydrogenase type II,
  • Short-chain type dehydrogenase/reductase XH98G2,
  • mitochondrial RNase P subunit 2,
  • mitochondrial ribonuclease P protein 2,

View in BioMuta


HSD17B10, hydroxysteroid (17-beta) dehydrogenase 10, is a member of the short-chain dehydrogenase/reductase superfamily. HSD17B10 functions in mitochondrial tRNA maturation and catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein is thought to play a role in the development of Alzheimer's disease. There are several alternatively spliced transcript variants, of which only two have been fully sequenced.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: HSD17B10


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data is available.

Performance Comment

HSD17B10 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place January 20–21, 2016 in Bethesda, Maryland.

Announcement 08/26/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Wednesday-Thursday, January 20-21, 2016, on the NCI campus. More information will be available later this summer.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.