Aliases:This biomarker is also known as:
- histone 1, H2bc,
- histone cluster 1, H2bc,
- Histone H2B.a,
- Histone H2B.1 A,
- Histone H2B.k,
- histone H2B type 1-C/E/F/G/I,
- histone H2B.1 A,
- Histone H2B.g,
- Histone H2B.l,
- H2B histone family, member L,
- histone H2B.l,
- Histone H2B.h,
From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
No additional prostate data available.
Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.