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This biomarker is also known as:
  • M6B,
  • MGC54284,
  • Q13491,
  • neuronal membrane glycoprotein M6-b,
  • M6b,
  • glycoprotein M6B,
  • MGC17150,
  • protolipid M6B,

View in BioMuta


GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is expressed in the brain and may be involved in cellular housekeeping functions. GPM6B is involved in the regulation of osteoblast function and bone formation and matrix vesicle release by osteoblasts. GPM6B may be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


GPM6B has been investigated as a serum biomarker for ovarian cancer as reported in European journals.

Performance Comment

GPM6B was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. GPM6B was not in the group of 13 selected for further validation.



Phase: One
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.