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GP73

Basics

Aliases:
This biomarker is also known as:
  • PSEC0257,
  • golgi membrane protein 1,
  • FLJ22634,
  • GOLPH2,
  • bA379P1.3,
  • golgi phosphoprotein 2,
  • FLJ23608,
  • GOLM1,
  • chromosome 9 open reading frame 155,
  • C9orf155,

View in BioMuta

Description…

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of the GP73 gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. Kladeny, RD. et al. 2000, found significant up-regulation of GOLPH2 expression in human hepatocyte cells infected with a recombinant adenovirus. EDRN investigator Block, TM et al. 2005, found that GP73 over-expression in serum correlate with liver cancer in woodchucks and humans. Chinnayian's lab reported that GP73 transcript was over-expressed in prostate cancer patients urine sediment (Laxman B. et al. 2008).

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: GOLM1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Liver

Attributes

Phase: Two
QA State: Under Review

Overview

Golgi protein-73 (GP73) is up-regulated in hepatocellular carcinoma (HCC).

Performance Comment

GP73 is used together with AFP-L3 in China for monitoring/risk assessment of cirrhotic patients for hepatocellular carcinoma (HCC).

Prostate

Attributes

Phase: Two
QA State: Under Review

Overview

GOLPH2 protein is highly expressed in seminomas and in Leydig cell tumours.

Performance Comment

Increased GOLPH2 (GP73) transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place January 20–21, 2016 in Bethesda, Maryland.

Announcement 08/26/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Wednesday-Thursday, January 20-21, 2016, on the NCI campus. More information will be available later this summer.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.