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This biomarker is also known as:
  • ESM-1,
  • endothelial cell-specific molecule 1,
  • endocan,

View in BioMuta


ESM1, a secreted protein containing multiple polyadenylation and mRNA instability signals, may have potent implications in lung endothelial cell-leukocyte interactions. It is expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. The expression of the ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Two transcript variants encoding different isoforms have been found for this gene.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Three
QA State: Under Review


ESM1 is a secreted tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.

Performance Comment

ESM1 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ESM1 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.