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ERG

Basics

Aliases:
This biomarker is also known as:
  • V-Ets Erythroblastosis Virus E26 Oncogene Like,
  • Transcriptional Regulator ERG (Transforming Protein ERG),
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog (Avian),
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Related,
  • V-Ets Erythroblastosis Virus E26 Oncogene Like (Avian),
  • Erg,
  • Transcriptional Regulator ERG,
  • P55,
  • Transforming Protein ERG,
  • Ets-Related,
  • TMPRSS2/ERG Fusion,

View in BioMuta

Description…

The ERG gene codes for the ERG protein, a transcription factor that is a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. Members of this family are involved in embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. ERG is mainly expressed in the nucleus. ERG is also involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Different isoforms arising from multiple alternatively spliced transcripts have been identified.

Attributes

QA State: Under Review
Type: Gene
Short Name:
HGNC Name: ERG

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

New Funding Opportunity: Biomarker Development Laboratories for the Early Detection Network: Applications Due May 23

Update: Pre-application webinar information now available.

The National Cancer Institute's Division of Cancer Prevention has released a new funding opportunity to solicit organ-specific applications for Biomarker Developmental Laboratories (BDLs), one of the four scientific units of the recently funded Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. BDLs are responsible for the discovery, development, characterization, and testing of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of cancers.

The existing BDLs are primarily focused on ovary and gastrointestinal cancers. The proposed BDLs (to be supported under this funding opportunity) should be focused on one or more of the following cancers: breast, prostate and other genitourinary organs, or lung. In addition, cancers with rapidly rising incidence rates, e.g., endometrial, hepatocellular, kidney, thyroid, oropharyngeal cancers, and/or cancers with unique etiology, e.g., mesothelioma, will be considered.

The newly funded units of the Early Detection Research Network will be announced later in April. Successful applicants have already been notified. Those researchers who were not successful during the last round of applications are encouraged to apply to this opportunity.