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EPCAM

Basics

Aliases:
This biomarker is also known as:
  • MH99,
  • CD326,
  • HNPCC8,
  • Ep-CAM,
  • epithelial cell adhesion molecule,
  • EGP-2,
  • EGP40,
  • 323/A3,
  • MIC18,
  • KSA,
  • ESA,
  • MK-1,
  • TACSTD1,
  • EGP314,
  • 17-1A,
  • KS1/4,
  • GA733-2,
  • DIAR5,
  • TACST-1,
  • HEA125,
  • MOC31,
  • TROP1,
  • EGP34,
  • M4S1,
  • tumor-associated calcium signal transducer 1,
  • Ly74,
  • CO-17A,
  • antigen identified by monoclonal antibody AUA1,

View in BioMuta

Description…

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. The EPCAM antigen, a single-pass type 1 membrane protein, is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. EPCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. EPCAM p-regulates the expression of FABP5, MYC and cyclins A and E. EPCAM is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: EPCAM

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement