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EPCAM

Basics

Aliases:
This biomarker is also known as:
  • epithelial cell adhesion molecule,
  • GA733-2,
  • EGP-2,
  • MK-1,
  • KS1/4,
  • KSA,
  • CD326,
  • antigen identified by monoclonal antibody AUA1,
  • TROP1,
  • HNPCC8,
  • EGP40,
  • M4S1,
  • tumor-associated calcium signal transducer 1,
  • HEA125,
  • TACST-1,
  • MOC31,
  • EGP34,
  • ESA,
  • CO-17A,
  • DIAR5,
  • TACSTD1,
  • 17-1A,
  • MH99,
  • Ep-CAM,
  • Ly74,
  • MIC18,
  • 323/A3,
  • EGP314,

View in BioMuta

Description…

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. The EPCAM antigen, a single-pass type 1 membrane protein, is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. EPCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. EPCAM p-regulates the expression of FABP5, MYC and cyclins A and E. EPCAM is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: EPCAM

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.