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This biomarker is also known as:
  • EGF-like-domain, multiple 6,
  • EGF repeat-containing protein 6,
  • EGF-like protein 6,
  • MAEG,
  • W80,
  • MAM and EGF domain containing,
  • MAM and EGF domains-containing gene protein,
  • Q8IUX8,
  • epidermal growth factor-like protein 6,

View in BioMuta


EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the regulation of cell cycle, proliferation, and developmental processes. The presence of a signal peptide indicates it is a secreted protein. The EGFL6 gene is expressed during early development.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


EGFL6 is a secreted tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.

Performance Comment

EGFL6 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of EGFL6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.