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DKK3

Basics

Aliases:
This biomarker is also known as:
  • Dkk-3,
  • hDkk-3,
  • Dickkopf-3,
  • REIC,
  • regulated in glioma,
  • Dickkopf-related protein 3,
  • dickkopf homolog 3 (Xenopus laevis),
  • RIG,
  • dickkopf (Xenopus laevis) homolog 3,

View in BioMuta

Description…

DKK3, a member of the dickkopf family, is a secreted protein containing two cysteine rich regions and involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of the DKK3 gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Highest expression in heart, brain, and spinal cord.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: DKK3

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement