Aliases:This biomarker is also known as:
- deleted in colorectal cancer protein,
- colorectal cancer suppressor,
- immunoglobulin superfamily DCC subclass member 1,
- tumor suppressor protein DCC,
- Immunoglobulin superfamily DCC subclass member 1,
- netrin receptor DCC,
- colorectal tumor suppressor,
- immunoglobulin superfamily, DCC subclass, member 1,
- Tumor suppressor protein DCC,
- Colorectal cancer suppressor,
- deleted in colorectal carcinoma,
DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Head & neck, NOS
No additional data available.
DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.
|QA State:||Under Review|
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