Aliases:This biomarker is also known as:
- MAC-inhibitory protein,
- CD59 antigen, complement regulatory protein,
- CD59 glycoprotein,
- CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344),
- MEM43 antigen,
- 1F5 antigen,
- Membrane inhibitor of reactive lysis,
- Membrane attack complex inhibition factor,
- 20 kDa homologous restriction factor,
CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific and is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
|QA State:||Under Review|
There are no datasets associated with this biomarker.