Aliases:This biomarker is also known as:
- chemokine (C-C motif) ligand 2,
- Monocyte chemotactic and activating factor,
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je),
- monocyte secretory protein JE,
- monocyte chemotactic protein 1,
- monocyte chemoattractant protein 1,
- Monocyte chemotactic protein 1,
- monocyte chemotactic and activating factor,
- small inducible cytokine subfamily A (Cys-Cys), member 2,
- Small-inducible cytokine A2,
- monocyte chemoattractant protein-1,
- Monocyte secretory protein JE,
- small-inducible cytokine A2,
- C-C motif chemokine 2,
- Monocyte chemoattractant protein 1,
From NCBI Gene: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
CCL2, also known as MCP-1, was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.