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CADM1

Basics

Aliases:
This biomarker is also known as:
  • Nectin-like protein 2,
  • immunoglobulin superfamily, member 4,
  • Necl-2,
  • BL2,
  • ST17,
  • sTSLC-1,
  • SYNCAM,
  • nectin-like 2,
  • SYNCAM1,
  • IGSF4A,
  • NECL2,
  • tumor suppressor in lung cancer 1,
  • IgSF4,
  • MGC149785,
  • TSLC1,
  • Synaptic cell adhesion molecule,
  • Spermatogenic immunoglobulin superfamily,
  • cell adhesion molecule 1,
  • sgIGSF,
  • MGC51880,
  • DKFZp686F1789,
  • IGSF4,
  • synCAM1,
  • RA175,

View in BioMuta

Description…

CADM1, a single-pass type 1 cell membrane protein, appears to be involved in several biolotical processes: Apoptosis, Cell adhesion, Differentiation, Immunity and Spermatogenesis. CADM1 appears to mediate homophilic cell-cell adhesion in a Ca2+-independent manner. It may also mediate heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. It may additionally contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, CADM1 may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo, and it may act as a synaptic cell adhesion molecule that drives synapse assembly. CADM1 may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. Finally, it may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: CADM1

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement