Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / BCAM

BCAM

Basics

Aliases:
This biomarker is also known as:
  • AU,
  • Lutheran antigen,
  • basal cell adhesion molecule (Lu and Au blood groups),
  • F8/G253 antigen,
  • LU,
  • Lutheran blood group (Auberger b antigen included),
  • B-CAM cell surface glycoprotein,
  • Auberger B antigen,
  • CD_antigen=CD239,
  • Basal cell adhesion molecule,
  • MSK19,
  • basal cell adhesion molecule (Lutheran blood group),
  • CD239,
  • Lutheran blood group glycoprotein,

View in BioMuta

Description…

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin alpha-5. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. It may also play a role in intracellular signalling. BCAM has wide tissue distribution (highest in the pancreas and very low in brain) and is closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Two transcript variants encoding different isoforms have been found for this gene.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: BCAM

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Three
QA State: Curated

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

Resources

No associated resources found.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.