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ATP6V1G1

Basics

Aliases:
This biomarker is also known as:
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1,
  • ATP6G,
  • ATP6J,
  • Vacuolar proton pump subunit G 1,
  • V-type proton ATPase subunit G 1,
  • DKFZp547P234,
  • ATP6GL,
  • vacuolar proton pump subunit M16,
  • vacuolar H(+)-ATPase subunit G 1,
  • V-ATPase subunit G 1,
  • Vma10,
  • vacuolar ATP synthase subunit M16,
  • vacuolar proton pump subunit G 1,
  • V-ATPase 13 kDa subunit 1,
  • Vacuolar proton pump subunit M16,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J,
  • ATP6G1,

View in BioMuta

Description…

ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ATP6V1G1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

ATP6V1G1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.