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This biomarker is also known as:
  • Vacuolar proton pump subunit M16,
  • V-ATPase subunit G 1,
  • V-type proton ATPase subunit G 1,
  • ATP6G,
  • Vacuolar proton pump subunit G 1,
  • DKFZp547P234,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1,
  • vacuolar proton pump subunit G 1,
  • V-ATPase 13 kDa subunit 1,
  • vacuolar proton pump subunit M16,
  • Vma10,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J,
  • ATP6GL,
  • ATP6G1,
  • vacuolar ATP synthase subunit M16,
  • vacuolar H(+)-ATPase subunit G 1,
  • ATP6J,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1,

View in BioMuta


ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

ATP6V1G1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.