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ANO1

Basics

Aliases:
This biomarker is also known as:
  • transmembrane protein 16A (eight membrane-spanning domains),
  • Tumor-amplified and overexpressed sequence 2,
  • tumor-amplified and overexpressed sequence 2,
  • oral cancer overexpressed 2,
  • FLJ10261,
  • discovered on gastrointestinal stromal tumors protein 1,
  • anoctamin-1,
  • TAOS2,
  • ORAOV2,
  • TMEM16A,
  • transmembrane protein 16A,
  • anoctamin 1, calcium activated chloride channel,
  • Discovered on gastrointestinal stromal tumors protein 1,
  • Oral cancer overexpressed protein 2,
  • DOG1,
  • Transmembrane protein 16A,

View in BioMuta

Description…

ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ANO1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.