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This biomarker is also known as:
  • Discovered on gastrointestinal stromal tumors protein 1,
  • TAOS2,
  • discovered on gastrointestinal stromal tumors protein 1,
  • Tumor-amplified and overexpressed sequence 2,
  • FLJ10261,
  • oral cancer overexpressed 2,
  • tumor-amplified and overexpressed sequence 2,
  • transmembrane protein 16A,
  • DOG1,
  • anoctamin-1,
  • transmembrane protein 16A (eight membrane-spanning domains),
  • Transmembrane protein 16A,
  • Oral cancer overexpressed protein 2,
  • TMEM16A,
  • anoctamin 1, calcium activated chloride channel,
  • ORAOV2,

View in BioMuta


ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.