Aliases:This biomarker is also known as:
- oral cancer overexpressed 2,
- anoctamin 1, calcium activated chloride channel,
- transmembrane protein 16A (eight membrane-spanning domains),
- tumor-amplified and overexpressed sequence 2,
- Oral cancer overexpressed protein 2,
- Tumor-amplified and overexpressed sequence 2,
- Discovered on gastrointestinal stromal tumors protein 1,
- transmembrane protein 16A,
- Transmembrane protein 16A,
- discovered on gastrointestinal stromal tumors protein 1,
ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.
ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.