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This biomarker is also known as:
  • GSH-FDH,
  • glutathione-dependent formaldehyde dehydrogenase,
  • EC,EC 1.1.1.-,EC,
  • ADHX,
  • Alcohol dehydrogenase class chi chain,
  • alcohol dehydrogenase class chi chain,
  • alcohol dehydrogenase class-3,
  • FALDH,
  • FDH,
  • formaldehyde dehydrogenase,
  • S-(hydroxymethyl)glutathione dehydrogenase,
  • alcohol dehydrogenase 5 (class III), chi polypeptide,
  • alcohol dehydrogenase (class III), chi polypeptide,
  • Alcohol dehydrogenase 5,
  • ADH-3,
  • GSNOR,
  • Alcohol dehydrogenase class-III,
  • Glutathione-dependent formaldehyde dehydrogenase,
  • alcohol dehydrogenase class-III,

View in BioMuta


ADH5 is a member of the alcohol dehydrogenase family. This protein forms a homodimer. ADH5 is ineffective in oxidizing ethanol, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. There are several non-transcribed pseuodogenes related to this gene.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

ADH5 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.