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ACO1

Basics

Aliases:
This biomarker is also known as:
  • iron regulatory protein 1,
  • IRP1,
  • IREB1,
  • EC 4.2.1.3,
  • iron-responsive element binding protein 1,
  • Ferritin repressor protein,
  • iron-responsive element-binding protein 1,
  • Aconitase,
  • cytoplasmic aconitate hydratase,
  • aconitase 1, soluble,
  • ACONS,
  • ferritin repressor protein,
  • IRE-BP 1,
  • Iron-responsive element-binding protein 1,
  • Citrate hydro-lyase,
  • IREBP1,
  • Iron regulatory protein 1,
  • aconitate hydratase,
  • IREBP,
  • citrate hydro-lyase,

View in BioMuta

Description…

aconitase 1, soluble

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: ACO1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

No associated resources found.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement