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ACO1

Basics

Aliases:
This biomarker is also known as:
  • iron-responsive element binding protein 1,
  • IREBP1,
  • cytoplasmic aconitate hydratase,
  • aconitase 1, soluble,
  • Aconitase,
  • Iron regulatory protein 1,
  • Iron-responsive element-binding protein 1,
  • iron-responsive element-binding protein 1,
  • ferritin repressor protein,
  • IREBP,
  • EC 4.2.1.3,
  • IRE-BP 1,
  • IREB1,
  • iron regulatory protein 1,
  • IRP1,
  • Citrate hydro-lyase,
  • Ferritin repressor protein,
  • aconitate hydratase,
  • ACONS,
  • citrate hydro-lyase,

View in BioMuta

Description…

aconitase 1, soluble

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: ACO1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

No associated resources found.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.