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This biomarker is also known as:
  • Citrate hydro-lyase,
  • Ferritin repressor protein,
  • ACONS,
  • IRE-BP 1,
  • Aconitase,
  • cytoplasmic aconitate hydratase,
  • IREBP,
  • aconitase 1, soluble,
  • aconitate hydratase,
  • citrate hydro-lyase,
  • EC,
  • IREBP1,
  • Iron-responsive element-binding protein 1,
  • Iron regulatory protein 1,
  • iron regulatory protein 1,
  • ferritin repressor protein,
  • IREB1,
  • iron-responsive element-binding protein 1,
  • iron-responsive element binding protein 1,
  • IRP1,

View in BioMuta


aconitase 1, soluble


QA State: Curated
Type: Gene
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: One
QA State: Under Review


No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


No associated resources found.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place January 20–21, 2016 in Bethesda, Maryland.

Announcement 08/26/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Wednesday-Thursday, January 20-21, 2016, on the NCI campus. More information will be available later this summer.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.