Objective

Investigate novel approaches how to employ the body’s r endogenous immune response as a natural "amplification strategy" for detection of prostate cancer and to apply this strategy to develop a serum-based test for detection of prostate cancer.

Program Description

A multidisciplinary group focused on discovery and development of new markers for early detection of prostate cancer based on molecular approaches for discovery of prostate auto-antibodies and auto-antigens in the serum of prostate cancer patients.

Specific Aims

• Characterize and validate the humoral immune response to AMACR in different patient cohorts.
• Employ high-throughput phage epitope microarrays to identify candidate humoral response markers of prostate cancer.
• Define and develop a multiplexed protein/epitope microarray to identify prostate cancer based on humoral response.

Contact Information

Arul M Chinnaiyan, MD, Ph.D.
> University of Michigan<br> Dept of Pathology & Urology
> 1301 Catherine Road<br> 4237 Medical Science I Bldg
> Ann Arbor, MI 48109-0602 <p>

Phone: (734) 936-1887
> Fax: (734) 763-6476<br> Email: arul@umich.edu