University of Michigan at Ann Arbor
Objective
Investigate novel approaches how to employ the body’s r endogenous immune response as a natural "amplification strategy" for detection of prostate cancer and to apply this strategy to develop a serum-based test for detection of prostate cancer.
Program Description
A multidisciplinary group focused on discovery and development of new markers for early detection of prostate cancer based on molecular approaches for discovery of prostate auto-antibodies and auto-antigens in the serum of prostate cancer patients.
Specific Aims
- Characterize and validate the humoral immune response to AMACR in different patient cohorts.
- Employ high-throughput phage epitope microarrays to identify candidate humoral response markers of prostate cancer.
- Define and develop a multiplexed protein/epitope microarray to identify prostate cancer based on humoral response.
Contact Information
Arul M Chinnaiyan, MD, Ph.D.
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University of Michigan<br>
Dept of Pathology & Urology
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1301 Catherine Road<br>
4237 Medical Science I Bldg
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Ann Arbor, MI 48109-0602
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Phone: (734) 936-1887
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Fax: (734) 763-6476<br>
Email: arul@umich.edu





